The bestselling author of Leonardo da Vinci and Steve Jobs returns with a gripping account of how the pioneering scientist Jennifer Doudna, along with her colleagues and rivals, launched a revolution that will allow us to cure diseases, fend off viruses, and enhance our children.
In the spring of 2012, the Berkeley biochemist Jennifer Doudna and her collaborators turned a curiosity of nature into an invention that will transform the future of the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions. It has already been deployed to cure deadly diseases, fight the coronavirus pandemic of 2020, and make inheritable changes in the genes of babies.
The development of CRISPR and the war against coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been an information-technology era, based on the microchip, the computer, and the internet. Now we are entering an even more momentous era, a life-science revolution. Children who study digital coding will be surpassed by those who study the code of life.
Should we use our new evolution-hacking powers to make us less susceptible to viruses and eliminate dreaded disorders? What a wonderful boon that would be! Right? And what about preventing congenital deafness or blindness? Or being very short? Or being depressed? Hmmm…How should we think about that? Should we allow parents, if they can afford it, to enhance the IQ or height or memory or muscles of their kids?
After helping to discover CRISPR, Doudna became a leader in wrestling with these moral and policy issues. Her life story illustrates that the key to innovation is connecting basic science to our everyday lives—moving discoveries from our labs to our bedsides—in ways that respect our moral values. It’s a thrilling detective tale that involves the most profound wonders of nature, from the origins of life to the future of our species.
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“Unfolds as an enthralling detective story, crackling with ambition and feuds, laboratories and conferences, Nobel laureates and self-taught mavericks. The book probes our common humanity without ever dumbing down the science, a testament to Isaacson’s own genius on the page.”
— O, The Oprah Magazine
“A gripping tale, showing how our new ability to hack evolution will soon start throwing us curveballs.”
— New Scientist“Marks the confluence of perfect writer, perfect subject and perfect timing. The result is almost certainly the most important book of the year.”
— Minneapolis Star-Tribune“A startling, insightful look at this lifesaving, hugely significant scientific advancement and the brilliant Doudna, who wrestles with the serious moral questions that accompany her creation…Who gets altered and saved and why?”
— AARP Magazine“Kathe Mazur skillfully narrates this clear and well-researched biography…Mazur’s personable delivery and measured pace help listeners access the science and connect to Doudna as a woman and a researcher. Her performance highlights the excitement of new discoveries.”
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Walter Isaacson is the author of highly acclaimed works of nonfiction, including several biographies that have made the #1 spot on the New York Times bestsellers list. A professor of history at Tulane University, he has been CEO of the Aspen Institute, chair of CNN, and editor of Time. Visit him at Isaacson.Tulane.edu.
Kathe Mazur has narrated many audiobooks, winning the prestigious Audie Award for best narration in 2014, being named a finalist for the Audie Award in 2013 and 2015, and winning several AudioFile Earphones Awards. As an actress, she can be seen as DDA Hobbs on The Closer and in the upcoming Major Crimes. She has worked extensively in film, theater, and television, including appearances on Grey’s Anatomy, Private Practice, House, Brothers and Sisters, Criminal Minds: Suspect Behavior, ER, Monk, and many others.