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3 out of 53 out of 53 out of 53 out of 53 out of 5 3.00 (138 ratings) (rate this audio book) Author: Eric Topol Narrator: Dick Hill Publisher: Tantor Format: Unabridged Audiobook Delivery: Instant Download Audio Length: Release Date:
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Until very recently, if you were to ask most doctors, they would tell you there were only two kinds of medicine: the quack kind, and the evidence-based kind. The former is baseless, and the latter based on the best information human effort could buy, with carefully controlled double-blind trials, hundreds of patients, and clear indicators of success.

Well, Eric Topol isn’t most doctors, and he suggests you entertain the notion of a third kind of medicine, one that will make the evidence-based state-of-the-art stuff look scarcely better than an alchemist trying to animate a homunculus in a jar. It turns out plenty of new medicines—although tested with what seem like large trials—actually end up revealing most of their problems only once they get out in the real world, with millions of people with all kinds of conditions mixing them with everything in the pharmacopeia. The unexpected interactions of drugs, patients, and diseases can be devastating. And the clear indicators of success often turn out to be minimal, often as small as one fewer person dying out of a hundred (or even a thousand), and often at exorbitant cost. How can we avoid these dangerous interactions and side-effects? How can we predict which person out of a hundred will be helped by a new drug, and which fatally harmed? And how can we avoid having to need costly drugs in the first place?

It sure isn’t by doing another four hundred-person trial. As Topol argues in The Creative Destruction of Medicine, it’s by bringing the era of big data to the clinic, laboratory, and hospital, with wearable sensors, smartphone apps, and whole-genome scans providing the raw materials for a revolution. With an optimism matched only by a realism gained through twenty-five years in a tough job, Topol proves the ideal guide to the medicine of the future—medicine he himself is deeply involved in creating.

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Quotes & Awards

  • “Eric Topol outlines the creative destruction of medicine that must be led by informed consumers.”

    Mehmet Oz, MD

  • “With his mature-sounding voice, Dick Hill creates an appealing performance that conveys wonder and curiosity about this cutting-edge summary of how digital technology will change healthcare.”

    AudioFile

  • “Topol weaves useful knowledge about how to evaluate the choices open to patients into this exciting account of the revolutionary changes we can expect.”

    Kirkus Reviews

  • AudioFile Earphones Award

Listener Opinions

  • 5 out of 55 out of 55 out of 55 out of 55 out of 5 by Casey | 1/19/2014

    " Will blow open the business of medicine, shifting from population-health to what I call "snowflake medicine" - truly targeted, personalized medical treatment. Won't happen today, but it will happen this decade. Bet on it. "

  • 4 out of 54 out of 54 out of 54 out of 54 out of 5 by David | 1/3/2014

    " I didn't learn much I didn't know but Topol provides a useful structure for reading. "

  • 5 out of 55 out of 55 out of 55 out of 55 out of 5 by Bud | 12/25/2013

    " Very thoughtful and stimulating description of the near trajectory of genomics, information technology, social media, and personal medicine. Eric Topol has real insights into revolutionary changes in the way medicine is about to be delivered. "

  • 5 out of 55 out of 55 out of 55 out of 55 out of 5 by Mary | 11/20/2013

    " Very good book, helpful explanations concerning genetics "

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About the Author

Eric Topol, MD, is a professor of innovative medicine, director of the Scripps Translational Science Institute, and founder of the world’s first cardiovascular gene bank at the Cleveland Clinic. He lives with his family in La Jolla, California.