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Extended Audio Sample Inside the OBriens: A Novel Audiobook, by Lisa Genova Click for printable size audiobook cover
0 out of 50 out of 50 out of 50 out of 50 out of 5 0.00 (0 ratings) (rate this audio book) Author: Lisa Genova Narrator: Skipp Sudduth Publisher: Simon & Schuster Audio Format: Unabridged Audiobook Delivery: Instant Download Audio Length: Release Date: April 2015 ISBN: 9781442382503
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From award-winning, New York Times bestselling author and neuroscientist Lisa Genova comes a powerful new novel that does for Huntington’s Disease what her debut Still Alice did for Alzheimer’s.

Joe O’Brien is a forty-four-year-old police officer from the Irish Catholic neighborhood of Charlestown, Massachusetts. A devoted husband, proud father of four children in their twenties, and respected officer, Joe begins experiencing bouts of disorganized thinking, uncharacteristic temper outbursts, and strange, involuntary movements. He initially attributes these episodes to the stress of his job, but as these symptoms worsen, he agrees to see a neurologist and is handed a diagnosis that will change his and his family’s lives forever: Huntington’s Disease.

Huntington’s is a lethal neurodegenerative disease with no treatment and no cure. Each of Joe’s four children has a 50 percent chance of inheriting their father’s disease, and a simple blood test can reveal their genetic fate. While watching her potential future in her father’s escalating symptoms, twenty-one-year-old daughter Katie struggles with the questions this test imposes on her young adult life. Does she want to know? What if she’s gene positive? Can she live with the constant anxiety of not knowing?

As Joe’s symptoms worsen and he’s eventually stripped of his badge and more, Joe struggles to maintain hope and a sense of purpose, while Katie and her siblings must find the courage to either live a life “at risk” or learn their fate.

Praised for writing that “explores the resilience of the human spirit” (The San Francisco Chronicle), Lisa Genova has once again delivered a novel as powerful and unforgettable as the human insights at its core. Download and start listening now!


Quotes & Awards

  • “Genova…compassionately details how an illness—this time Huntington’s disease—can destroy not only the afflicted but those who love them as well.”

    People magazine

  • “This novel of siblings rocked by their father’s Huntington’s disease is a total tearjerker, but ultimately it’s a tribute to family love.”


  • “An intimate, heartbreaking look at life with Huntington’s disease.”

    Marie Claire

  • “An unsparing, heart-piercing portrait…compelling…enlightening.”

    Washington Post

  • “Compelling and masterful.”

    New York Journal of Books

  • “Skipp Sudduth’s performance of Genova’s exploration of Huntington’s disease makes the science of this inherited, incurable, degenerative nerve disease very personal…Sudduth’s no-nonsense delivery and unemotional handling of this highly emotional subject are exactly right. As the O’Brien children learn that each has a 50/50 chance of inheriting the illness and that a simple blood test can tell if they have the gene, Sudduth makes their awakening to the deadly possibilities palpable…Clear-eyed and heartrending, this is top-notch listening.”


  • An April 2015 LibraryReads Pick
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About the Author
Author Lisa Genova

Lisa Genova is the author of the New York Times bestsellers Left Neglected, Inside the O’Briens, and Still Alice, among other books. Still Alice was adapted into an Oscar-winning film starring Julianne Moore, Alec Baldwin, and Kristen Stewart. She has been featured in major media and travels worldwide speaking about the neurological diseases that she writes about. She graduated from Bates College with a degree in biopsychology and holds a PhD in neuroscience from Harvard University.